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Article

Hierarchical assembly of presynaptic components in defined C. elegans synapses.

Nature neuroscience - 1 Dec 2006

Patel Maulik R, Lehrman Emily K, Poon Vivian Y, Crump Justin G, Zhen Mei, Bargmann Cornelia I, Shen Kang

Abstract excerpt

The presynaptic regions of axons accumulate synaptic vesicles, active zone proteins and periactive zone proteins. However, the rules for orderly recruitment of presynaptic components are not well understood. We systematically examined molecular mechanisms of presynaptic development in egg-laying synapses of Caenorhabditis elegans, demonstrating that two scaffolding molecules, SYD-1 and SYD-2, have key roles in...

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Identifiers

PMID: 17115039
DOI: 10.1038/nn1806
PMCID: PMC3917495

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Hierarchical assembly of presynaptic components in defined C. elegans synapses.PMID 17115039Read ↗

RSY-1 is a local inhibitor of presynaptic assembly in C. elegans.Semantic proximity Read ↗

The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.Semantic proximity Read ↗

The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans.Semantic proximity Read ↗

SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.Semantic proximity Read ↗

The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission.Semantic proximity Read ↗

NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins.Semantic proximity Read ↗

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.Semantic proximity Read ↗

Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α.Semantic proximity Read ↗

The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.Semantic proximity Read ↗

Synaptogenesis.Semantic proximity Read ↗

Assembly of synaptic active zones requires phase separation of scaffold molecules.Semantic proximity Read ↗

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