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Article

Unc-51 controls active zone density and protein composition by downregulating ERK signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Jan 2009

Wairkar Yogesh P, Toda Hirofumi, Mochizuki Hiroaki, Furukubo-Tokunaga Katsuo, Tomoda Toshifumi, Diantonio Aaron

Abstract excerpt

Efficient synaptic transmission requires the apposition of neurotransmitter release sites opposite clusters of postsynaptic neurotransmitter receptors. Transmitter is released at active zones, which are composed of a large complex of proteins necessary for synaptic development and function. Many active zone proteins have been identified, but little is known of the mechanisms that ensure that each active zone...

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Identifiers

PMID: 19144852
DOI: 10.1523/JNEUROSCI.3848-08.2009
PMCID: PMC2741695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Unc-51 controls active zone density and protein composition by downregulating ERK signaling.PMID 19144852Read ↗

PP2A and GSK-3beta act antagonistically to regulate active zone development.Semantic proximity Read ↗

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Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release.Semantic proximity Read ↗

Preferential localization of glutamate receptors opposite sites of high presynaptic release.Semantic proximity Read ↗

Blobby is a synaptic active zone assembly protein required for memory in Drosophila.Semantic proximity Read ↗

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Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses.Semantic proximity Read ↗

ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot.Semantic proximity Read ↗

UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites.Semantic proximity Read ↗

A Glutamate Homeostat Controls the Presynaptic Inhibition of Neurotransmitter Release.Semantic proximity Read ↗

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Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation.Semantic proximity Read ↗

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