Article
Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma.
Brain pathology (Zurich, Switzerland) - 1 Jan 2018
Pagès Mélanie, Beccaria Kevin, Boddaert Nathalie, Saffroy Raphaël, Besnard Aurore, Castel David, Fina Frédéric, Barets Doriane, Barret Emilie, Lacroix Ludovic, Bielle Franck, Andreiuolo Felipe, Tauziède-Espariat Arnault, Figarella-Branger Dominique, Puget Stéphanie, Grill Jacques, Chrétien Fabrice, Varlet Pascale
Abstract excerpt
Ganglioglioma (GG) is a grade I tumor characterized by alterations in the MAPK pathway, including BRAF V600E mutation. Recently, diffuse midline glioma with an H3 K27M mutation was added to the WHO 2016 classification as a new grade IV entity. As co-occurrence of H3 K27M and BRAF V600E mutations has been reported in midline tumors and anaplastic GG, we searched for BRAF V600E and H3 K27M mutations in a series of...
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