Article
Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas.
Scientific reports - 20 May 2020
Mosaab Amal, El-Ayadi Moatasem, Khorshed Eman N, Amer Nada, Refaat Amal, El-Beltagy Mohamed, Hassan Zeinab, Soror Sameh H, Zaghloul Mohamed Saad, El-Naggar Shahenda
Abstract excerpt
Pediatric high-grade gliomas (HGG) are rare aggressive tumors that present a prognostic and therapeutic challenge. Diffuse midline glioma, H3K27M-mutant is a new entity introduced to HGG in the latest WHO classification. In this study we evaluated the presence of H3K27M mutation in 105 tumor samples histologically classified into low-grade gliomas (LGG) (n = 45), and HGG (n = 60). Samples were screened for the...
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