A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation.

doi:10.1007/s00401-023-02651-4

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Article

A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation.

Acta neuropathologica - 8 Dec 2023

Auffret Lucie, Ajlil Yassine, Tauziède-Espariat Arnault, Kergrohen Thomas, Puiseux Chloé, Riffaud Laurent, Blouin Pascale, Bertozzi Anne-Isabelle, Leblond Pierre, Blomgren Klas, Froelich Sébastien, Picca Alberto, Touat Mehdi, Sanson Marc, Beccaria Kévin, Blauwblomme Thomas, Dangouloff-Ros Volodia, Boddaert Nathalie, Varlet Pascale, Debily Marie-Anne, Grill Jacques, Castel David

Abstract excerpt

Diffuse midline gliomas (DMG) H3 K27-altered are incurable grade 4 gliomas and represent a major challenge in neuro-oncology. This tumour type is now classified in four subtypes by the 2021 edition of the WHO Classification of the Central Nervous System (CNS) tumours. However, the H3.3-K27M subgroup still appears clinically and molecularly heterogeneous. Recent publications reported that rare patients presenting...

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PMID: 38066305
DOI: 10.1007/s00401-023-02651-4
PMCID: PMC10709479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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