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Article

An adult case of diffuse midline glioma with H3 K27M mutation.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Dec 2020

Tu Jin-Hua, Piao Yue-Shan, Lu De-Hong, Wang Lei-Ming, Liu Li, Bai Dong-Yu, Han Hai-Wei, Lin Yi-Kai, Zhong Shan

Abstract excerpt

Cartilaginous metaplasia is rare in primary central nervous system (CNS) neoplasms and has not been described in the histone 3 (H3) gene (H3) with a substitution of lysine to methionine (H3 K27M mutant) diffuse midline glioma before. Here, we report a case of H3 K27M mutant diffuse midline glioma with cartilaginous metaplasia in a 56-year-old woman. Magnetic resonance imaging (MRI) revealed a ring-enhanced lesion...

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PMID: 32954563
DOI: 10.1111/neup.12689

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