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Article

An Emerging Pediatric CNS Tumor: Imaging Evaluation of H3K27M and BRAF V600E Comutated Midline Tumors.

AJNR. American journal of neuroradiology - 4 Mar 2026

Rameh Vanessa, Aker Loai, Vajapeyam Sridhar, Ziaei Alireza, Yeo Kee Kiat, Alves Cesar, Baird Lissa C, Fehnel Katie P, Wright Karen, Chi Susan, Lidov Hart G, Alexandrescu Sanda, Poussaint Tina Y

Abstract excerpt

BACKGROUND AND PURPOSE: Diffuse midline gliomas (DMGs) with concurrent H3K27M and BRAF V600E mutations represent a rare and poorly studied subset of pediatric CNS tumors. While traditionally associated with poor prognosis, recent evidence suggests that mitogen-activated protein kinase (MAPK) pathway alterations may confer improved outcomes in select cases. This study aims to explore the imaging characteristics of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40962421
DOI: 10.3174/ajnr.A9006
PMCID: PMC12964442

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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