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Characteristics of H3 K27M-mutant gliomas in adults.

Neuro-oncology - 1 Aug 2017

Meyronet David, Esteban-Mader Maud, Bonnet Charlotte, Joly Marie-Odile, Uro-Coste Emmanuelle, Amiel-Benouaich Alexandra, Forest Fabien, Rousselot-Denis Cécilia, Burel-Vandenbos Fanny, Bourg Véronique, Guyotat Jacques, Fenouil Tanguy, Jouvet Anne, Honnorat Jérôme, Ducray François

Abstract excerpt

BACKGROUND: Diffuse H3 K27M-mutant gliomas occur primarily in children but can also be encountered in adults. The aim of this study was to describe the characteristics of H3 K27M-mutant gliomas in adults. METHODS: We analyzed the characteristics of 21 adult H3 K27M-mutant gliomas and compared them with those of 135 adult diffuse gliomas without histone H3 and without isocitrate dehydrogenase (IDH) mutation...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Astrocytoma
Brain Neoplasms
Child
Female
Glioma
Histones
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

Male

Middle Aged

Mutation

Promoter Regions, Genetic

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 28201752
DOI: 10.1093/neuonc/now274
PMCID: PMC5570304

Genes

MGMT
BRAF
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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