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Article

Evaluating H3F3A K27M and G34R/V somatic mutations in a cohort of pediatric brain tumors of different and rare histologies.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Feb 2021

Oliveira Vinicius Fernandes, De Sousa Graziella Ribeiro, Dos Santos Antonio Carlos, Saggioro Fabiano Pinto, Machado Helio Rubens, de Oliveira Ricardo Santos, Tone Luiz Gonzaga, Valera Elvis Terci

Abstract excerpt

PURPOSE: Somatic mutations on H3 histone are currently considered a genetic hallmark for midline pediatric high-grade gliomas (HGGs). Yet, different tumor histologies have been occasionally described to carry these mutations. Since histone modifications can lead to major epigenetic changes with direct impact on prognosis and treatment, we thought to investigate the occurrence of H3F3A K27M and G34R/V mutations in...

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PMID: 32766947
DOI: 10.1007/s00381-020-04852-8

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