Article
Diffuse hemispheric glioma with H3 p.K28M (K27M) mutation: Unusual non-midline presentation of diffuse midline glioma, H3 K27M-altered?
Journal of neuropathology and experimental neurology - 19 Apr 2024
Donev Kliment, Sundararajan Vanitha, Johnson Derek, Balan Jagadheshwar, Chambers Meagan, Paulson Vera A, Scherpelz Kathryn P, Abdullaev Zied, Quezado Martha, Cimino Patrick J, Pratt Drew, Valerio Ediel, Alves de Castro João Vıctor, Carraro Dirce Maria, Torrezan Giovana Tardin, Wolff Beatriz Martins, Kulikowski Leslie Domenici, Costa Felipe D'Almeida, Aldape Kenneth, Ida Cristiane M
Abstract excerpt
Diffuse midline glioma, H3 K27-altered (DMG-H3 K27) is an aggressive group of diffuse gliomas that predominantly occurs in pediatric patients, involves midline structures, and displays loss of H3 p.K28me3 (K27me3) expression by immunohistochemistry and characteristic genetic/epigenetic profile. Rare examples of a diffuse glioma with an H3 p.K28M (K27M) mutation and without involvement of the midline structures,...
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