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Article

Midline Glioma in Adults: Clinicopathological, Genetic, and Epigenetic Analysis

1 Jan 2020

Abstract excerpt

The histone H3K27M-mutant diffuse midline glioma is often seen in children and has a very poor prognosis regardless of its histological grade. Although it can occur in adults, few studies on adult cases have been reported. We examined adult midline glioma cases for their histological grade, presence of H3K27M mutation, and expression of related factors-enhancer of zeste homolog 2 (EZH2), H3K27me3, p16, and...

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PMID: 31902873
DOI: 10.2176/nmc.oa.2019-0168

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