Article
Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location.
Neuro-oncology - 10 Jan 2018
Karremann Michael, Gielen Gerrit H, Hoffmann Marion, Wiese Maria, Colditz Niclas, Warmuth-Metz Monika, Bison Brigitte, Claviez Alexander, van Vuurden Dannis G, von Bueren André O, Gessi Marco, Kühnle Ingrid, Hans Volkmar H, Benesch Martin, Sturm Dominik, Kortmann Rolf-Dieter, Waha Andreas, Pietsch Torsten, Kramm Christof M
Abstract excerpt
Background: The novel entity of "diffuse midline glioma, H3 K27M-mutant" has been defined in the 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). Tumors of this entity arise in CNS midline structures of predominantly pediatric patients and are associated with an overall dismal prognosis. They are defined by K27M mutations in H3F3A or HIST1H3B/C,...
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