Article
Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016
Carr Michael I, Roderick Justine E, Zhang Hong, Woda Bruce A, Kelliher Michelle A, Jones Stephen N
Abstract excerpt
The p53 tumor suppressor acts as a guardian of the genome by preventing the propagation of DNA damage-induced breaks and mutations to subsequent generations of cells. We have previously shown that phosphorylation of the Mdm2 oncoprotein at Ser394 by the ATM kinase is required for robust p53 stabilization and activation in cells treated with ionizing radiation, and that loss of Mdm2 Ser394 phosphorylation leads to...
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