Article
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Genes & development - 1 May 2001
Maya R, Balass M, Kim S T, Shkedy D, Leal J F, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan M B, Katzir E, Oren M
Abstract excerpt
The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomimetic agents is largely dependent on the ATM kinase. p53 is phosphorylated by ATM shortly after DNA damage, resulting in enhanced stability and activity of p53. The Mdm2 oncoprotein is a pivotal negative regulator of...
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