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Article

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.

Cancer cell - 1 Apr 2006

Toledo Franck, Krummel Kurt A, Lee Crystal J, Liu Chung-Wen, Rodewald Luo-Wei, Tang Mengjia, Wahl Geoffrey M

Abstract excerpt

The mechanisms by which Mdm2 and Mdm4 (MdmX) regulate p53 remain controversial. We generated a mouse encoding p53 lacking the proline-rich domain (p53DeltaP). p53DeltaP exhibited increased sensitivity to Mdm2-dependent degradation and decreased transactivation capacity, correlating with deficient...

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Source

Identifiers

PMID: 16616333
DOI: 10.1016/j.ccr.2006.03.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16616333-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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