Article
Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity.
Genes & development - 1 Jul 2011
Wang Yunyuan V, Leblanc Mathias, Fox Norma, Mao Jian-Hua, Tinkum Kelsey L, Krummel Kurt, Engle Dannielle, Piwnica-Worms David, Piwnica-Worms Helen, Balmain Allan, Kaushansky Kenneth, Wahl Geoffrey M
Abstract excerpt
Cell cycle regulation in hematopoietic stem cells (HSCs) is tightly controlled during homeostasis and in response to extrinsic stress. p53, a well-known tumor suppressor and transducer of diverse stress signals, has been implicated in maintaining HSC quiescence and self-renewal. However, the mechanisms that control its activity in HSCs, and how p53 activity contributes to HSC cell cycle control, are poorly...
Topics
- Animals
- Cells, Cultured
- Cyclin-Dependent Kinase Inhibitor p21
- Female
- Gamma Rays
- Gene Dosage
- Gene Expression Regulation
- Gene Knock-In Techniques
- Hematopoietic Stem Cells