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Article

Mdm2 and Mdm4 loss regulates distinct p53 activities.

Molecular cancer research : MCR - 1 Jun 2008

Barboza Juan A, Iwakuma Tomoo, Terzian Tamara, El-Naggar Adel K, Lozano Guillermina

Abstract excerpt

Mutational inactivation of p53 is a hallmark of most human tumors. Loss of p53 function also occurs by overexpression of negative regulators such as MDM2 and MDM4. Deletion of Mdm2 or Mdm4 in mice results in p53-dependent embryo lethality due to constitutive p53 activity. However, Mdm2(-/-) and M...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Share to Tumor Suppressor Protein p53

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Source

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Identifiers

PMID: 18567799
DOI: 10.1158/1541-7786.MCR-07-2079
PMCID: PMC2699947

Genes

MDM2
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18567799-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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