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Article

Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases.

Cancer cell - 7 Jul 2009

Wang Yunyuan V, Leblanc Mathias, Wade Mark, Jochemsen Aart G, Wahl Geoffrey M

Abstract excerpt

Mdmx is a critical negative regulator of the p53 pathway that is stoichiometrically limiting in some tissues. Posttranslational modification and degradation of Mdmx after DNA damage have been proposed to be essential for p53 activation. We tested this model in vivo, where critical stoichiometric relationships are preserved. We generated an Mdmx mutant mouse in which three conserved serines (S341, S367, S402)...

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Identifiers

PMID: 19573810
DOI: 10.1016/j.ccr.2009.05.008
PMCID: PMC2758524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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