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Article

Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance.

Molecular and cellular biology - 1 Aug 2005

Kulikov Roman, Boehme Karen A, Blattner Christine

Abstract excerpt

The Mdm2 oncoprotein regulates abundance and activity of the p53 tumor suppressor protein. For efficient degradation of p53, Mdm2 needs to be phosphorylated at several contiguous residues within the central conserved domain. We show that glycogen synthase kinase 3 (GSK-3) phosphorylated the Mdm2 protein in vitro and in vivo in the central domain. Inhibition of GSK-3 rescued p53 from degradation in an...

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Identifiers

PMID: 16055726
DOI: 10.1128/MCB.25.16.7170-7180.2005
PMCID: PMC1190268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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