Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity.

Genes & development - 1 Sept 2013

Pant Vinod, Xiong Shunbin, Jackson James G, Post Sean M, Abbas Hussein A, Quintás-Cardama Alfonso, Hamir Amirali N, Lozano Guillermina

Abstract excerpt

The p53-Mdm2 feedback loop is perceived to be critical for regulating stress-induced p53 activity and levels. However, this has never been tested in vivo. Using a genetically engineered mouse with mutated p53 response elements in the Mdm2 P2 promoter, we show that feedback loop-deficient Mdm2(P2/P2) mice are viable and aphenotypic and age normally. p53 degradation kinetics after DNA damage in radiosensitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Feedback, Physiological
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Protein Denaturation

Share to Protein Stability

Share to Proto-Oncogene Proteins c-mdm2

Share to Radiation, Ionizing

Share to Radiation Tolerance

Source

Open in PubMed Open full text

Identifiers

PMID: 23973961
DOI: 10.1101/gad.227249.113
PMCID: PMC3778240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity.PMID 23973961Read ↗

Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity.Semantic proximity Read ↗

Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.Semantic proximity Read ↗

Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.Semantic proximity Read ↗

Targeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in CancerSemantic proximity Read ↗

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation.Semantic proximity Read ↗

MDM2 is a Central Node in the p53 Pathway: 12 Years and CountingSemantic proximity Read ↗

Mdm2 links genotoxic stress and metabolism to p53.Semantic proximity Read ↗

Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.Semantic proximity Read ↗

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity.Semantic proximity Read ↗

The regulation of MDM2 oncogene and its impact on human cancers.Semantic proximity Read ↗

Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo.Semantic proximity Read ↗

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.