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Article

Tissue-specific and age-dependent effects of global Mdm2 loss.

The Journal of pathology - 1 Aug 2014

Zhang Yun, Xiong Shunbin, Li Qin, Hu Sophia, Tashakori Mehrnoosh, Van Pelt Carolyn, You Mingjian James, Pageon Laura, Lozano Guillermina

Abstract excerpt

Mdm2, an E3 ubiquitin ligase, negatively regulates the tumour suppressor p53. In this study we utilized a conditional Mdm2 allele, Mdm2(FM) , and a CAG-CreER tamoxifen-inducible recombination system to examine the effects of global Mdm2 loss in adult mice. Two different tamoxifen injection regimens caused 100% lethality of Mdm2(FM) (/-) ;CAG-CreER mice; both radio-sensitive and radio-insensitive tissues were...

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Identifiers

PMID: 24789767
DOI: 10.1002/path.4368
PMCID: PMC4151977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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