Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation Control of p53 DNA-Binding Cooperativity Balances Tumorigenesis and Aging

1 Sept 2020

Abstract excerpt

Abstract Posttranslational modifications are essential for regulating the transcription factor p53, which binds DNA in a highly cooperative manner to control expression of a plethora of tumor-suppressive programs. Here we show at the biochemical, cellular, and organismal level that the cooperative nature of DNA binding is reduced by phosphorylation of highly conserved serine residues (human S183/S185, mouse S180)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32873634
DOI: 10.1158/0008-5472.can-20-2002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation Control of p53 DNA-Binding Cooperativity Balances Tumorigenesis and AgingPMID 32873634Read ↗

Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 ResponsesSemantic proximity Read ↗

Crippling p53 activities via knock-in mutations in mouse models.Semantic proximity Read ↗

Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumorsSemantic proximity Read ↗

The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange.Semantic proximity Read ↗

BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21Semantic proximity Read ↗

Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis.Semantic proximity Read ↗

The tumor suppressor p53: Cancer and agingSemantic proximity Read ↗

A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic MalignanciesSemantic proximity Read ↗

Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in miceSemantic proximity Read ↗

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment.Semantic proximity Read ↗

The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repairSemantic proximity Read ↗

Mutant p53 regulates a distinct gene set by a mode of genome occupancy that is shared with wild type.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.