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Article

Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.

Genes & development - 1 Jan 2021

Humpton Timothy J, Nomura Koji, Weber Julia, Magnussen Helge M, Hock Andreas K, Nixon Colin, Dhayade Sandeep, Stevenson David, Huang Danny T, Strathdee Douglas, Blyth Karen, Vousden Karen H

Abstract excerpt

The p53 tumor suppressor protein is a potent activator of proliferative arrest and cell death. In normal cells, this pathway is restrained by p53 protein degradation mediated by the E3-ubiquitin ligase activity of MDM2. Oncogenic stress releases p53 from MDM2 control, so activating the p53 response. However, many tumors that retain wild-type p53 inappropriately maintain the MDM2-p53 regulatory loop in order to...

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Identifiers

PMID: 33334825
DOI: 10.1101/gad.341875.120
PMCID: PMC7778261

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