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Article

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation.

Molecular and cellular biology - 1 Jan 2003

Mendrysa Susan M, McElwee Matthew K, Michalowski Jennifer, O'Leary Kathleen A, Young Karen M, Perry Mary Ellen

Abstract excerpt

The function of the p53 tumor suppressor protein must be highly regulated because p53 can cause cell death and prevent tumorigenesis. In cultured cells, the p90MDM2 protein blocks the transcriptional activation domain of p53 and also stimulates the degradation of p53. Here we provide the first conclusive demonstration that p90MDM2 constitutively regulates p53 activity in homeostatic tissues. Mice with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12509446
DOI: 10.1128/MCB.23.2.462-473.2003
PMCID: PMC151546

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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