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Article

GPNMB ameliorates mutant TDP-43-induced motor neuron cell death.

Journal of neuroscience research - 1 Aug 2017

Nagahara Yuki, Shimazawa Masamitsu, Ohuchi Kazuki, Ito Junko, Takahashi Hitoshi, Tsuruma Kazuhiro, Kakita Akiyoshi, Hara Hideaki

Abstract excerpt

Glycoprotein nonmetastatic melanoma protein B (GPNMB) aggregates are observed in the spinal cord of amyotrophic lateral sclerosis (ALS) patients, but the detailed localization is still unclear. Mutations of transactive response DNA binding protein 43kDa (TDP-43) are associated with neurodegenerative diseases including ALS. In this study, we evaluated the localization of GPNMB aggregates in the spinal cord of ALS...

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Source

Identifiers

PMID: 27935101
DOI: 10.1002/jnr.23999

Genes

GPNMB
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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