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Article

TDP-43 regulates endogenous retrovirus-K viral protein accumulation.

Neurobiology of disease - 1 Oct 2016

Manghera Mamneet, Ferguson-Parry Jennifer, Douville Renée N

Abstract excerpt

The concomitant expression of neuronal TAR DNA binding protein 43 (TDP-43) and human endogenous retrovirus-K (ERVK) is a hallmark of ALS. Since the involvement of TDP-43 in retrovirus replication remains controversial, we sought to evaluate whether TDP-43 exerts an effect on ERVK expression. In this study, TDP-43 bound the ERVK promoter in the context of inflammation or proteasome inhibition, with no effect on...

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Source

Identifiers

PMID: 27370226
DOI: 10.1016/j.nbd.2016.06.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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