Article

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

2021-08-04

Abstract excerpt

Modestly increased expression of transactive response DNA binding protein ( TDP-43 ) gene have been reported in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neuromuscular diseases. However, whether this modest elevation triggers neurodegeneration is not known. Although high levels of TDP-43 overexpression have been modeled in mice and shown to cause early death, models with low-le...

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Literature Corpus work: e46bce00-b0e0-59bf-9d2d-637dea25483b
DOI: 10.1101/2021.08.04.455119

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