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Article

HSPB1 mutations causing hereditary neuropathy in humans disrupt non-cell autonomous protection of motor neurons.

Experimental neurology - 1 Nov 2017

Heilman Patrick L, Song SungWon, Miranda Carlos J, Meyer Kathrin, Srivastava Amit K, Knapp Amy, Wier Christopher G, Kaspar Brian K, Kolb Stephen J

Abstract excerpt

Heat shock protein beta-1 (HSPB1), is a ubiquitously expressed, multifunctional protein chaperone. Mutations in HSPB1 result in the development of a late-onset, distal hereditary motor neuropathy type II (dHMN) and axonal Charcot-Marie Tooth disease with sensory involvement (CMT2F). The functional consequences of HSPB1 mutations associated with hereditary neuropathy are unknown. HSPB1 also displays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28797631
DOI: 10.1016/j.expneurol.2017.08.002
PMCID: PMC5612892

Genes

HSPB1
SOD1

Variants

Provenance

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