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Article

ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice.

Acta neuropathologica communications - 27 Nov 2024

Horiuchi Mai, Watanabe Seiji, Komine Okiru, Takahashi Eiki, Kaneko Kumi, Itohara Shigeyoshi, Shimada Mayuko, Ogi Tomoo, Yamanaka Koji

Abstract excerpt

Nuclear clearance and cytoplasmic aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) are pathological hallmarks of amyotrophic lateral sclerosis (ALS) and its pathogenic mechanism is mediated by both loss-of-function and gain-of-toxicity of TDP-43. However, the role of TDP-43 gain-of-toxicity in oligodendrocytes remains unclear. To investigate the impact of excess TDP-43 on oligodendrocytes, we established...

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Identifiers

PMID: 39605053
DOI: 10.1186/s40478-024-01893-x
PMCID: PMC11603663

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