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Article

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats.

The EMBO journal - 3 Jul 2013

Tong Jianbin, Huang Cao, Bi Fangfang, Wu Qinxue, Huang Bo, Liu Xionghao, Li Fang, Zhou Hongxia, Xia Xu-Gang

Abstract excerpt

Mutation of Tar DNA-binding protein 43 (TDP-43) is linked to amyotrophic lateral sclerosis. Although astrocytes have important roles in neuron function and survival, their potential contribution to TDP-43 pathogenesis is unclear. Here, we created novel lines of transgenic rats that express a mutant form of human TDP-43 (M337V substitution) restricted to astrocytes. Selective expression of mutant TDP-43 in...

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Identifiers

PMID: 23714777
DOI: 10.1038/emboj.2013.122
PMCID: PMC3981181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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