Article
The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis.
Scientific reports - 1 Jan 2012
Tanaka Hirotaka, Shimazawa Masamitsu, Kimura Masataka, Takata Masafumi, Tsuruma Kazuhiro, Yamada Mitsunori, Takahashi Hitoshi, Hozumi Isao, Niwa Jun-ichi, Iguchi Yohei, Nikawa Takeshi, Sobue Gen, Inuzuka Takashi, Hara Hideaki
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease characterized by the loss of motor neurons. Despite substantial research, the causes of ALS remain unclear. Glycoprotein nonmetastatic melanoma protein B (GPNMB) was identified as an ALS-related factor using DNA microarray analysis with mutant superoxide dismutase (SOD1(G93A)) mice. GPNMB was greatly induced in the spinal...
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