Article
TDP-43 activates microglia through NF-κB and NLRP3 inflammasome.
Experimental neurology - 1 Nov 2015
Zhao Weihua, Beers David R, Bell Shaughn, Wang Jinghong, Wen Shixiang, Baloh Robert H, Appel Stanley H
Abstract excerpt
Transactive response DNA-binding protein-43 (TDP-43) is a multifunctional nucleic acid binding protein present in ubiquitinated inclusions in tissues of patients with amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration (FTLD). The ALS-associated mutations in the glycine-rich C-terminal domain of TDP-43 established a causal link between TDP-43 and disease, and conferred both loss- and...
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