Article

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

2021-05-06

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Modestly elevated levels of transactive response DNA binding protein (<italic>TDP-43</italic>) gene have been reported in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neuromuscular diseases. However, whether this modest elevation triggers neurodegeneration is not known. Although high levels of TDP-43 overexpression have been mode...

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Literature Corpus work: 9a664d59-7aa5-5818-9d24-cf6341a839bf
DOI: 10.21203/rs.3.rs-455895/v1

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