Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cortical Thickness and Microstructural White Matter Changes Detect Amnestic Mild Cognitive Impairment.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Wang Zan, Dai Zhengjia, Shu Hao, Liu Duan, Guo Qihao, He Yong, Zhang Zhijun

Abstract excerpt

Both the apolipoprotein E (APOE) ɛ4 allele and amnestic mild cognitive impairment (aMCI) are considered to be risk factors for Alzheimer's disease (AD). The primary aim of this study was to determine whether the aMCI-related abnormality in gray matter (GM) cortical thickness and white matter (WM) tracts integrity would be modified by the APOE genotype. A total of 146 older adults, including 64 aMCI patients (28...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrophy
Share to Cerebral Cortex
Share to Cognitive Dysfunction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diffusion Magnetic Resonance Imaging

Share to Image Processing, Computer-Assisted

Share to ROC Curve

Share to Statistics, Nonparametric

Share to White Matter

Source

Identifiers

PMID: 27911306
DOI: 10.3233/JAD-160724

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cortical Thickness and Microstructural White Matter Changes Detect Amnestic Mild Cognitive Impairment.PMID 27911306Read ↗

Decreased white matter integrity in neuropsychologically defined mild cognitive impairment is independent of cortical thinning.Semantic proximity Read ↗

The interaction of APOE genotype by age in amnestic mild cognitive impairment: a voxel-based morphometric study.Semantic proximity Read ↗

Selective brain gray matter atrophy associated with APOE ε4 and MAPT H1 in subjects with mild cognitive impairment.Semantic proximity Read ↗

Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics.Semantic proximity Read ↗

Atrophy and dysfunction of parahippocampal white matter in mild Alzheimer's disease.Semantic proximity Read ↗

Precuneus degeneration in nondemented elderly individuals with APOE ɛ4: Evidence from structural and functional MRI analyses.Semantic proximity Read ↗

Tract-based spatial statistics: application to mild cognitive impairment.Semantic proximity Read ↗

Interaction of white matter hyperintensities (WMHs) and apolipoprotein E (APOE) genotypes on cognition in patients with amnestic mild cognitive impairment (aMCI).Semantic proximity Read ↗

The APOE ɛ4 allele modulates brain white matter integrity in healthy adults.Semantic proximity Read ↗

The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studiesSemantic proximity Read ↗

APOE ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly.Semantic proximity Read ↗

Cortical thinning in temporal pole, a core region in Alzheimer’s disease, in non-demented, middle-aged <i>APOE</i> -ε4 and <i>PICALM</i> -AA/AG carriersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.