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Article

Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics.

Journal of neurology, neurosurgery, and psychiatry - 1 Jan 2011

Dickerson Bradford C, Wolk David A

Abstract excerpt

OBJECTIVE: To investigate whether some patients with very mild Alzheimer's disease (AD) demonstrate disproportionate executive dysfunction relative to amnesia and how this relates to functional impairment in daily life, future clinical decline, APOE genotype and regional cortical thickness measured from MRI scan data. METHODS: The Alzheimer's Disease Neuroimaging Initiative dataset was interrogated for a primary...

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Identifiers

PMID: 20562467
DOI: 10.1136/jnnp.2009.199505
PMCID: PMC3023235

Genes

APOE

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