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Article

The APOE ɛ4 allele modulates brain white matter integrity in healthy adults.

Molecular psychiatry - 1 Sept 2011

Heise V, Filippini N, Ebmeier K P, Mackay C E

Abstract excerpt

The Apolipoprotein E (APOE) ɛ4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is also associated with structural gray matter and functional brain changes in healthy young, middle-aged and elderly subjects. Because APOE is implicated in brain mechanisms associated with white matter (WM) development and repair, we investigated the potential role played by the APOE...

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Identifiers

PMID: 20820167
DOI: 10.1038/mp.2010.90

Genes

APOE

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