Article
Decreased white matter integrity in neuropsychologically defined mild cognitive impairment is independent of cortical thinning.
Journal of the International Neuropsychological Society : JINS - 1 Sept 2013
Stricker Nikki H, Salat David H, Foley Jessica M, Zink Tyler A, Kellison Ida L, McFarland Craig P, Grande Laura J, McGlinchey Regina E, Milberg William P, Leritz Elizabeth C
Abstract excerpt
Improved understanding of the pattern of white matter changes in early and prodromal Alzheimer’s disease (AD) states such as mild cognitive impairment (MCI) is necessary to support earlier preclinical detection of AD, and debate remains whether white matter changes in MCI are secondary to gray matter changes. We applied neuropsychologically based MCI criteria to a sample of normally aging older adults; 32...
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