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Article

Precuneus degeneration in nondemented elderly individuals with APOE ɛ4: Evidence from structural and functional MRI analyses.

Human brain mapping - 1 Jan 2017

Chen Yaojing, Liu Zhen, Zhang Junying, Chen Kewei, Yao Li, Li Xin, Gong Gaolang, Wang Jun, Zhang Zhanjun

Abstract excerpt

Neurodegenerative diseases such as Alzheimer's disease (AD) have been recognized to exhibit disease-specific brain vulnerability patterns. Apolipoprotein E (APOE) ɛ4 allele imparts a high genetic risk of developing AD. Whether the APOE ɛ4 allele damages the brain when cognitive functions are still intact is important to understand, especially for possible early detection and intervention. This study aimed to...

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Identifiers

PMID: 27593520
DOI: 10.1002/hbm.23359
PMCID: PMC6866889

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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