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Article

Targeting naturally occurring epitope variants of hepatitis C virus with high-affinity T-cell receptors.

The Journal of general virology - 1 Mar 2017

Zhang Huajun, Zhang Jianbing, Chen Lei, Weng Zhiming, Tian Ye, Zhao Haifeng, Li Youjia, Chen Lin, Liang Zhaoduan, Zheng Hongjun, Zhao Wenzhuo, Zhong Shi, Li Yi

Abstract excerpt

Hepatitis C virus (HCV) readily establishes chronic infection, which is characterized by failure of virus-specific CD8+ T cells. HCV uses epitope mutation and T-cell exhaustion to escape from the host immune response. Previously, we engineered high-affinity T-cell receptors (HATs) targeting human immunodeficiency virus escape mutants. In this study, the affinity of a T-cell receptor specific for the...

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Share to CD3 Complex
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to HLA-A2 Antigen

Share to Immunodominant Epitopes

Share to Receptors, Antigen, T-Cell

Share to Single-Chain Antibodies

Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 27902325
DOI: 10.1099/jgv.0.000656
PMCID: PMC5797947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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