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Article

Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus.

The Journal of biological chemistry - 23 Dec 2011

Wang Yong, Keck Zhen-Yong, Saha Anasuya, Xia Jinming, Conrad Fraser, Lou Jianlong, Eckart Michael, Marks James D, Foung Steven K H

Abstract excerpt

A potent neutralizing antibody to a conserved hepatitis C virus (HCV) epitope might overcome its extreme variability, allowing immunotherapy. The human monoclonal antibody HC-1 recognizes a conformational epitope on the HCV E2 glycoprotein. Previous studies showed that HC-1 neutralizes most HCV genotypes but has modest potency. To improve neutralization, we affinity-matured HC-1 by constructing a library of...

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Share to Antibodies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22002064
DOI: 10.1074/jbc.M111.290783
PMCID: PMC3243554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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