Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2011

Miles John J, Thammanichanond Duangtawan, Moneer Sarah, Nivarthi Usha K, Kjer-Nielsen Lars, Tracy Samantha L, Aitken Campbell K, Brennan Rebekah M, Zeng Weiguang, Marquart Louise, Jackson David, Burrows Scott R, Bowden David S, Torresi Joseph, Hellard Margaret, Rossjohn Jamie, McCluskey James, Bharadwaj Mandvi

Abstract excerpt

Hepatitis C virus (HCV) infection causes significant morbidity and mortality worldwide. T cells play a central role in HCV clearance; however, there is currently little understanding of whether the disease outcome in HCV infection is influenced by the choice of TCR repertoire. TCR repertoires use...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epitopes, T-Lymphocyte
Share to Hepacivirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to HLA-A Antigens

Share to HLA-B Antigens

Share to Immune Evasion

Share to Immunodominant Epitopes

Share to Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 21160049
DOI: 10.4049/jimmunol.1003167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21160049-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection.PMID 21160049Read ↗

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant.Semantic proximity Read ↗

Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections.Semantic proximity Read ↗

Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral AntigensSemantic proximity Read ↗

Hepatitis C virus--T-cell responses and viral escape mutations.Semantic proximity Read ↗

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection.Semantic proximity Read ↗

High‐throughput T‐cell receptor sequencing across chronic liver diseases reveals distinct disease‐associated repertoiresSemantic proximity Read ↗

Human leukocyte antigen–associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution†Semantic proximity Read ↗

Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing.Semantic proximity Read ↗

Selection of conserved epitopes from hepatitis C virus for pan-populational stimulation of T-cell responses.Semantic proximity Read ↗

Antigen-Specific TCR Signatures of Cytomegalovirus InfectionSemantic proximity Read ↗

Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire.Semantic proximity Read ↗

Anti-hepatitis C virus T-cell immunity in the context of multiple exposures to the virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.