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Structural and biochemical insights into HCV envelope proteins for germline-targeting vaccines

2026-05-01

Abstract excerpt

Despite effective antivirals, Hepatitis C remains a global health burden, reflecting the difficulty of eliciting broadly neutralizing antibodies (bnAbs). For the Hepatitis C virus, bnAb responses are biased toward VH1-69–encoded Abs targeting a conserved epitope on the E2 glycoprotein, suggesting that effective immunogens must engage the corresponding germline B cell receptors. However, the structural basis of ger...

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Literature Corpus work
4f1195d7-bc86-5c00-93d5-f6a7f62b35ce
DOI
10.64898/2026.04.27.721052
Open publication

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Structural and biochemical insights into HCV envelope proteins for germline-targeting vaccinesDOI 10.64898/2026.04.27.721052
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