Article

Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins

2022-11-16

Abstract excerpt

<title>Abstract</title> <p>An effective preventive vaccine for hepatitis C virus (HCV) remains a major unmet need. Antigenic region 3 (AR3) on the E1E2 envelope glycoprotein complex overlaps with the CD81 receptor binding site and represents an important epitope for vaccine design aimed at inducing broadly neutralizing antibodies (bNAbs). Most AR3 bNAbs utilize the <italic>V</italic><sub><italic>H</italic></sub><...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 136c4ef3-4cbe-5d4e-a6d2-f9f45ac93bcb
DOI: 10.21203/rs.3.rs-2255626/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteinsDOI 10.21203/rs.3.rs-2255626/v1Read

Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteinsSemantic proximity Read

Structural and biochemical insights into HCV envelope proteins for germline-targeting vaccinesSemantic proximity Read

Structural and genetic signatures of two classes of HCV E2 neutralizing face antibodies from non-human primates immunized with a recombinant E1E2Semantic proximity Read

Can Broadly Neutralizing Monoclonal Antibodies Lead to a Hepatitis C Virus Vaccine?Semantic proximity Read

Genetic and structural insights into broad neutralization of hepatitis C virus by human V H 1-69 antibodiesSemantic proximity Read

Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trialSemantic proximity Read

Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design.Semantic proximity Read

Hepatitis C Virus E1E2 Structure, Diversity, and Implications for Vaccine DevelopmentSemantic proximity Read

Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trialSemantic proximity Read

Structural perspectives on HCV humoral immune evasion mechanisms.Semantic proximity Read

Hepatitis C virus E1 protein-specific linear B-cell epitopes, pan-genotype reactivity, and functional relevance.Semantic proximity Read

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus.Semantic proximity Read