Article
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012
Giang Erick, Dorner Marcus, Prentoe Jannick C, Dreux Marlène, Evans Matthew J, Bukh Jens, Rice Charles M, Ploss Alexander, Burton Dennis R, Law Mansun
Abstract excerpt
Hepatitis C virus (HCV) infects ∼2% of the world's population. It is estimated that there are more than 500,000 new infections annually in Egypt, the country with the highest HCV prevalence. An effective vaccine would help control this expanding global health burden. HCV is highly variable, and an effective vaccine should target conserved T- and B-cell epitopes of the virus. Conserved B-cell epitopes overlapping...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Antibody Specificity
- Cell Line, Tumor
- Enzyme-Linked Immunosorbent Assay
- Epitopes, B-Lymphocyte
- Genotype
- HEK293 Cells
- Hepacivirus
- Hepatitis C