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Article

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2014

Nivarthi Usha K, Gras Stephanie, Kjer-Nielsen Lars, Berry Richard, Lucet Isabelle S, Miles John J, Tracy Samantha L, Purcell Anthony W, Bowden David S, Hellard Margaret, Rossjohn Jamie, McCluskey James, Bharadwaj Mandvi

Abstract excerpt

Mutations in T cell epitopes are implicated in hepatitis C virus (HCV) persistence and can impinge on vaccine development. We recently demonstrated a narrow bias in the human TCR repertoire targeted at an immunodominant, but highly mutable, HLA-B*0801-restricted epitope ((1395)HSKKKCDEL(1403) [HSK]). To investigate if the narrow TCR repertoire facilitates CTL escape, structural and biophysical studies were...

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Share to Antigenic Variation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA-B8 Antigen

Share to Immunodominant Epitopes

Share to Protein Engineering

Share to Protein Stability

Share to Receptors, Antigen, T-Cell

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Identifiers

PMID: 25355921
DOI: 10.4049/jimmunol.1401357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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