Article
A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes.
Protein & cell - 1 Apr 2014
Sun Lu, Zhang Yu, Zhao Bao, Deng Mengmeng, Liu Jun, Li Xin, Hou Junwei, Gui Mingming, Zhang Shuijun, Li Xiaodong, Gao George F, Meng Songdong
Abstract excerpt
Cytotoxic T cells (CTLs) play a key role in the control of Hepatitis B virus (HBV) infection and viral clearance. However, most of identified CTL epitopes are derived from HBV of genotypes A and D, and few have been defined in virus of genotypes B and C which are more prevalent in Asia. As HBV core protein (HBc) is the most conservative and immunogenic component, in this study we used an overlapping 9-mer peptide...
Topics
- Adult
- Amino Acid Sequence
- Animals
- Binding Sites
- Epitopes
- Female
- Genotype
- HEK293 Cells
- HLA-A2 Antigen
- Hepatitis B Core Antigens
- Hepatitis B virus
- Humans
- Hydrogen Bonding
- Male