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Article

Selection of conserved epitopes from hepatitis C virus for pan-populational stimulation of T-cell responses.

Clinical & developmental immunology - 1 Jan 2013

Molero-Abraham Magdalena, Lafuente Esther M, Flower Darren R, Reche Pedro A

Abstract excerpt

The hepatitis C virus (HCV) is able to persist as a chronic infection, which can lead to cirrhosis and liver cancer. There is evidence that clearance of HCV is linked to strong responses by CD8 cytotoxic T lymphocytes (CTLs), suggesting that eliciting CTL responses against HCV through an epitope-based vaccine could prove an effective means of immunization. However, HCV genomic plasticity as well as the...

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Identifiers

PMID: 24348677
DOI: 10.1155/2013/601943
PMCID: PMC3856138

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