Article

Consensus native-like hepatitis C virus E1E2 engages broadly neutralizing antibody precursors

2026-08-26

Abstract excerpt

A major goal for hepatitis C virus (HCV) vaccine development is to elicit broadly neutralizing antibodies (bNAbs) against the E1E2 glycoprotein complex located on the viral surface. Inducing HCV bNAbs requires engagement of their germline B cell precursors. HCV glycoproteins usually do not bind and activate inferred germline precursors of bNAbs (igl-bNAbs), possibly because most circulating strains contain non-con...

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Literature Corpus work: ee64fd5a-9cad-5daf-80be-6ec54ef63ee7
DOI: 10.64898/2026.08.25.746952

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