Article
Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection.
Journal of virology - 1 Aug 1997
Diepolder H M, Gerlach J T, Zachoval R, Hoffmann R M, Jung M C, Wierenga E A, Scholz S, Santantonio T, Houghton M, Southwood S, Sette A, Pape G R
Abstract excerpt
In acute hepatitis C virus infection, 50 to 70% of patients develop chronic disease. Considering the low rate of spontaneous viral clearance during chronic hepatitis C infection, the first few months of interaction between the patient's immune system and the viral population seem to be crucial in...
Topics
- Acute Disease
- Adolescent
- Adult
- Alleles
- CD4-Positive T-Lymphocytes
- Epitopes
- Female
- HLA-DR Antigens
- Hepatitis C
- Humans
- Male
- Middle Aged
- Viral Nonstructural Proteins