Article
Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms Modify the Associations of Plasma Glycine and Serine With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris in WENBIT (Western Norway B Vitamin Intervention Trial).
Circulation. Cardiovascular genetics - 1 Dec 2016
Ding Yunpeng, Pedersen Eva R, Svingen Gard F T, Helgeland Øyvind, Gregory Jesse F, Løland Kjetil H, Meyer Klaus, Tell Grethe S, Ueland Per M, Nygård Ottar K
Abstract excerpt
BACKGROUND: Serine and glycine interconversion and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1)-mediated 1-carbon transfer are the major sources of methyl groups for 1-carbon metabolism. Recently, plasma glycine and a common polymorphism in MTHFD1 have been associated with risk of acute myocardial infarction (AMI). It is, therefore, of interest to explore if these 2 pathways interact in relation to AMI....
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